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About

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Research Interests Mechanism of action of apoptotic and cytoprotective bile acids Submillimolar concentrations of cytotoxic bile acids BAs induce cell death via apoptosis. On the other hand, several cytoprotective BAs acids were shown to prevent apoptosis in the same concentration range. Still, the mechanisms by which BAs trigger these opposite signaling effects remain unclear. We are interested on the characterization of such mechanisms, particularly on the impact of apoptotic and cytoprotective bile acids on the properties of biological membranes and on the activity of apoptotic proteins. Deoxycholic acid modulates cell death signaling through changes in mitochondrial membrane properties J. In this work, the impact of cytotoxic and cytoprotective bile acids on the biophysical properties of membranes from different hepatocyte cellular compartments was quantified. Cytotoxic bile acids were shown to specifically modulate mitochondrial outer membrane order, strongly suggesting that bile acid-induced apoptosis is associated with modulation of the properties of mitochondrial membranes.

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That was the best experience ever! As soon as I covered most of the basic concepts I decided to go for applications and the theoretical foundation. That was the way I migrated to the area of Machine Learning.

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My main research field focuses on the discovery and application of biomarkers in severe mental illnesses, namely bipolar disorder, major depressive disorder, and schizophrenia. I started in this field in during my psychiatric training and in published what is perhaps the first proposal of employment of blood biomarkers as an adjunctive tool for the differential diagnosis of bipolar and unipolar depression. My masters degree investigated and proposed the protein brain-derived neurotrophic factor BDNF as a biomarker of disease activity in bipolar disorder, showing it decreased in mania and depression, reflecting severity of the mood states, and normal in euthymia. My thesis originated two papers that were published at Molecular Psychiatry, the leading journal in my field, in and Michael Berk, a well-known expert in bipolar disorder.

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Dataset on schistosomiasis control using potassium usnate against Biomphalaria glabrata at different developmental stage and Schistosoma mansoni cercariae. Altered endotoxin responsiveness in healthy children with Down syndrome. Data set of the toxic effects of divaricatic acid depside on Biomphalaria glabrata and Schistosoma mansoni cercariae. Potassium usnate toxicity against embryonic stages of the snail Biomphalaria glabrata and Schistosoma mansoni cercariae. Epub Aug 8.

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